Вадастуксимаб талирин

Rec. INN (наименование, зарегистрированное ВОЗ)

USAN (наименование, принятое к употреблению в США)

1436390-64-5

immunoglobulin G1-kappa, anti-[Homo sapiens CD33 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67)], chimeric monoclonal antibody conjugated to the pyrrolobenzodiazepine (PDB) dimer SGD-1882;
gamma1 heavy chain (1-447) [Mus musculus VH (IGHV1- 85*01 -(IGHD)-IGHJ4*01) [8.8.10] (1-117) -Homo sapiens IGHG1*01, G1m17,1 (CH1 (118-215), hinge (216-230), CH2 S3>C (239) (231-340), CH3 (341-445), CHS (446- 447)) (118-447)], (220-214')-disulfide with kappa light chain (1'-214') [Mus musculus V-KAPPA (IGKV14-111*01 -Homo sapiens IGKJ4*01) [6.3.9] (1'-107') -Homo sapiens IGKC*01, Km3 (108'-214')]; dimer (226-226'':229-229'')- bisdisulfide; conjugated, on two site-specific drug attachment engineered cysteines (C239, C239''), to a maximum of 2 pyrrolobenzodiazepine (PDB) dimers SGD1882, each via a cleavable (valine-alanine dipeptide as cathepsine B cleavage site) maleimidocaproyl type linker

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