Таркоцимаб тедромер
Tarcocimab tedromerМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2411896-53-0
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens VEGFA (vascular endothelial growth factor A, VEGF-A, VEGF)], humanized monoclonal antibody, conjugated via a linker to a nine-armed star polymer with phosphorylcholine polymer end groups;
gamma1 heavy chain humanized (1-453) [VH (Homo sapiens IGHV3-30*02 (75.8%) -(IGHD) -IGHJ4*01 (93.3%), CDR-IMGT [8.8.16] (26-33.51-58.97-112)) (1-123) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1, G1v14 CH2 A1.3, A1.2 (CH1 R120>K (220) (124-221), hinge 1-15 (222-236), CH2 L1.3>A (240), L1.2>A (241), G1>A (243) (237-346), CH3 E12 (362), M14 (364), L123>C (449) (347-451), CHS (452-453)) (124-453)], (226-214')-disulfide with kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-16*01 (87.4%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (232-232'':235-235'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1SV lacking the glutamine synthetase (GS-KO) gene, glycoform alfa, substituted at an average of one S atom of cysteine residues 449 and 449'' with the (3RS)-1-[1,1,1-tris({3-[2-(2,2,2-tris{[(2-{α-(bromo / ethoxy / hydro / hydroxy)poly[1-(10,10-dimethyl-6-oxido-6-oxo-2,5,7-trioxa-10-aza-6λ5-phosphaundecan-10-ium-1-oyl)-1-methylethane-1,2-diyl]-ω-yl}-2-methylpropanoyl)oxy]methyl}ethoxy)acetamido]propanamido}methyl)-16,32-dioxo-3,6,9,12,19,22,25,28-octaoxa-15,31-diazatetratriacontan-34-yl]-2,5-dioxopyrrolidin-1-yl (tedromer) group
gamma1 heavy chain humanized (1-453) [VH (Homo sapiens IGHV3-30*02 (75.8%) -(IGHD) -IGHJ4*01 (93.3%), CDR-IMGT [8.8.16] (26-33.51-58.97-112)) (1-123) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1, G1v14 CH2 A1.3, A1.2 (CH1 R120>K (220) (124-221), hinge 1-15 (222-236), CH2 L1.3>A (240), L1.2>A (241), G1>A (243) (237-346), CH3 E12 (362), M14 (364), L123>C (449) (347-451), CHS (452-453)) (124-453)], (226-214')-disulfide with kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-16*01 (87.4%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (232-232'':235-235'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1SV lacking the glutamine synthetase (GS-KO) gene, glycoform alfa, substituted at an average of one S atom of cysteine residues 449 and 449'' with the (3RS)-1-[1,1,1-tris({3-[2-(2,2,2-tris{[(2-{α-(bromo / ethoxy / hydro / hydroxy)poly[1-(10,10-dimethyl-6-oxido-6-oxo-2,5,7-trioxa-10-aza-6λ5-phosphaundecan-10-ium-1-oyl)-1-methylethane-1,2-diyl]-ω-yl}-2-methylpropanoyl)oxy]methyl}ethoxy)acetamido]propanamido}methyl)-16,32-dioxo-3,6,9,12,19,22,25,28-octaoxa-15,31-diazatetratriacontan-34-yl]-2,5-dioxopyrrolidin-1-yl (tedromer) group
Структура
![Структура Таркоцимаб тедромер Структура Таркоцимаб тедромер](/images/as/tarcocimab-tedromer.png)
Иностранные названия
- Tarcocimabum tedromerum (латинское)
- Tarcocimab tedromer (английское)
- Tarcocimab tedromer (немецкое)
- Tarcocimab tédromère (французское)
- Tarcocimab tedrómero (испанское)
Подробнее по теме
Узнайте дополнительные сведения о действующем веществе Таркоцимаб тедромер: