Сабестомиг

Rec. INN (наименование, зарегистрированное ВОЗ)

2648346-74-9

immunoglobulin G1-kappa/lambda, anti-[Homo sapiens PDCD1 (programmed cell death 1, PD1, PD-1, CD279) and HAVCR2 (hepatitis A virus cellular receptor 2, T cell immunoglobulin and mucin domains family member 3, TIM3, TIM-3, TIMD3, CD366)], humanized and Homo sapiens monoclonal antibody, bispecific, bivalent;gamma1 heavy chain anti-PDCD1 humanized (1-452) [VH humanized (Homo sapiens IGHV3-48*01 (92.9%) -(IGHD) -IGHJ4*01 (93.3%) L123>T (117), CDR-IMGT [8.8.15] (26-33.51-58.97-111)) (1-122) -Homo sapiens IGHG1*03, G1m3, nG1m1 CH1 R120, CH3 E12, M14, G1v39 CH2 F1.3, E1.2, S116, G1v33 CH3 S22, A24, V86 (hole) (CH1 R120 (219) (123-220), hinge 1-15 (221-235), CH2 L1.3>F (239), L1.2>E (240), P116>S (336) (236-345), CH3 E12 (361), M14 (363), Y5>C (354), T22>S (371), L24>A (373), Y86>V (412) (346-450), CHS (451-452)) (123-452)], (225-219')-disulfide with kappa light chain anti-PDCD1 humanized (1'-219') [V-KAPPA humanized (Homo sapiens IGKV3D-7*01 (81.1%) -IGKJ2*02 (100%), CDR-IMGT [11.3.9] (27-37.55-57.94-102)) (1'-112') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (158), V101 (196) (113'-219')];
gamma1 heavy chain anti-HAVCR2 Homo sapiens (1''-452'') [VH (Homo sapiens IGHV3-23*01 (99.0%) -(IGHD) -IGHJ4*01 (93.3%), CDR-IMGT [8.8.15] (26-33.51-58.97-111)) (1''-122'') -Homo sapiens IGHG1*03, G1m3, nG1m1 CH1 R120, CH3 E12, M14, G1v39 CH2 F1.3, E1.2, S116, G1v32 CH3 W22 (knob), G1v58 CH1 C5, h V5 (CH1 F5>C (131), R120 (219) (123''-220''), hinge 1-15 C5>V (225) (221''-235''), CH2 L1.3>F (239), L1.2>E (240), P116>S (336) (236''-345''), CH3 S10>C (359), E12 (361), M14 (363), T22>W (371) (346''-450''), CHS (451''-452'')) (123''-452'')], (131''-123''')-disulfide with lambda light chain anti-HAVCR2 Homo sapiens (1'''-214''') [V-LAMBDA (Homo sapiens IGLV3-21*01 (94.8%) -IGKJ2*02 (90.9%), CDR-IMGT [6.3.11] (26-31.49-51.88-98)) (1'''-108''') -Homo sapiens IGLC2*01 (98.1%) LC2v58 C10, V126 (S10>C (123), C126>V (213)) (109'''-214''')]; dimer (231-231'':234-234'':354-359'')-trisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CATS, glycoform alfa

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