Ремтолумаб
RemtolumabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
Drugbank
DB15128
CAS
1791410-27-9
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens IL17A (interleukin 17A, IL-17A) and Homo sapiens TNF (tumor necrosis factor (TNF) superfamily member 2, TNFSF2, TNF-alpha, TNFA)], Homo sapiens monoclonal antibody, tetravalent bispecific;
gamma1 heavy chain (1-587) [Homo sapiens VH anti-TNF (IGHV3-9*01 (93.90%) -(IGHD) -IGHJ4*01) [8.8.14] (1- 121) -10-mer bis(tetraglycyl-seryl) linker (122-132) -Homo sapiens VH' anti-IL17A (IGHV1-69*01 (85.70%) -(IGHD) - IGHJ6*01) [8.8.19] (132-257) -IGHG1*01, G1m17,1 (CH1 (258-355), hinge (356-370), CH2 (371-480), CH3 (481- 585), CHS (586-587)) (258-587)], (360-331')-disulfide with kappa light chain (1'-331') [Homo sapiens V-KAPPA antiTNF (IGKV1-27*01 (95.80%) -IGKJ2*01) [6.3.9] (1'-107') - Homo sapiens V-KAPPA anti-IL17A (IGKV6-21*01 (90.50%) -IGKJ3*01) [6.3.9] (118'-224') -IGKC*01, Km3 (225'-213')]; dimer (366-366'':369-369'')-bisdisulfide
gamma1 heavy chain (1-587) [Homo sapiens VH anti-TNF (IGHV3-9*01 (93.90%) -(IGHD) -IGHJ4*01) [8.8.14] (1- 121) -10-mer bis(tetraglycyl-seryl) linker (122-132) -Homo sapiens VH' anti-IL17A (IGHV1-69*01 (85.70%) -(IGHD) - IGHJ6*01) [8.8.19] (132-257) -IGHG1*01, G1m17,1 (CH1 (258-355), hinge (356-370), CH2 (371-480), CH3 (481- 585), CHS (586-587)) (258-587)], (360-331')-disulfide with kappa light chain (1'-331') [Homo sapiens V-KAPPA antiTNF (IGKV1-27*01 (95.80%) -IGKJ2*01) [6.3.9] (1'-107') - Homo sapiens V-KAPPA anti-IL17A (IGKV6-21*01 (90.50%) -IGKJ3*01) [6.3.9] (118'-224') -IGKC*01, Km3 (225'-213')]; dimer (366-366'':369-369'')-bisdisulfide
Структура
Иностранные названия
- Remtolumabum (латинское)
- Remtolumab (английское)
- Remtolumab (немецкое)
- Remtolumab (французское)
- Remtolumab (испанское)
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