Рефанезумаб

Rec. INN (наименование, зарегистрированное ВОЗ)

DB14908

1233953-61-1

immunoglobulin G1-kappa, anti-[Homo sapiens MAG (myelin associated glycoprotein, sialic acid binding Ig-like lectin 4A, SIGLEC4A, SIGLEC-4A)], humanized monoclonal antibody;
gamma1 heavy chain (1-456) [humanized VH (Homo sapiens IGHV7-4-1*02 (93.90%) -(IGHD)-IGHJ4*01) [8.8.19] (1-126) -Homo sapiens IGHG1*01, G1m17,1 (CH1 (127-224), hinge (225-239), CH2 L1.2>A (244), G1>A (246) (240-349), CH3 (350-454), CHS (455-456)) (127- 456)], (229-219')-disulfide with kappa light chain (1’-219’) [humanized V-KAPPA (Homo sapiens IGKV4-1*01 (95.00%) -IGKJ2*01) [12.3.8] (1'-112') -Homo sapiens IGKC*01, Km3 (113'-219')]; dimer (235-235":238-238")- bisdisulfide

C₆₆₀₈H₁₀₁₅₆N₁₇₃₂O₂₀₆₄S₄₄

148298,64 г/моль

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