Наратуксимаб эмтансин
Naratuximab emtansineМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
Drugbank
DB15453
CAS
1607824-64-5
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiensCD37 (tetraspanin-26, TSPAN26)], chimeric monoclonal antibody conjugated to maytansinoid DM1;
gamma1 heavy chain (1-444) [Mus musculus VH (IGHV2- 3*01 -(IGHD)- IGHJ3*01) [8.7.9] (1-115) -Homo sapiens IGHG1*01, Gm17,1 (CH1 (116-213), hinge (214-228), CH2 (229-338), CH3 (339-443), CHS K2>del (444)) (116-444)], (218-214')-disulfide with kappa light chain (1'-214') [Mus musculus V-KAPPA (IGKV12-46*01 - IGKJ1*01) [6.3.9] (1'- 107') -Homo sapiens IGKC*01, Km3 (108'-214')]; dimer (224-224'':227-227'')-bisdisulfide; conjugated, on an average of 3 to 4 lysyl, to maytansinoid DM1 via a succinimidyl-4-(N-maleimidomethyl) cyclohexane-1-carboxylate (SMCC) linker forming a nonreducible thioether bond
gamma1 heavy chain (1-444) [Mus musculus VH (IGHV2- 3*01 -(IGHD)- IGHJ3*01) [8.7.9] (1-115) -Homo sapiens IGHG1*01, Gm17,1 (CH1 (116-213), hinge (214-228), CH2 (229-338), CH3 (339-443), CHS K2>del (444)) (116-444)], (218-214')-disulfide with kappa light chain (1'-214') [Mus musculus V-KAPPA (IGKV12-46*01 - IGKJ1*01) [6.3.9] (1'- 107') -Homo sapiens IGKC*01, Km3 (108'-214')]; dimer (224-224'':227-227'')-bisdisulfide; conjugated, on an average of 3 to 4 lysyl, to maytansinoid DM1 via a succinimidyl-4-(N-maleimidomethyl) cyclohexane-1-carboxylate (SMCC) linker forming a nonreducible thioether bond
Структура
Иностранные названия
- Naratuximabum emtansinum (латинское)
- Naratuximab emtansine (английское)
- Naratuximab emtansin (немецкое)
- Naratuximab emtansine (французское)
- Naratuximab emtansina (испанское)
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