Маплирпацепт

Rec. INN (наименование, зарегистрированное ВОЗ)

2631667-06-4

human signal-regulatory protein alpha (SIRPα, tyrosine-protein phosphatase non-receptor type substrate 1, inhibitory receptor SHPS-1) N-terminal fragment (1-118) variant (L¹⁴>S, T²⁰>S, T²²>I, R²⁴>H, A²⁷>V, G⁴⁵>A, D⁶⁵>E, L⁶⁶>S, N⁷⁰>E, R⁷⁷>S, G⁷⁹>S, D¹⁰¹ deleted, V¹⁰²>T¹⁰¹) fused to a human immunoglobulin G4 C-terminal Fc fragment (119-347), variant (S¹²⁸>P), disulfide bridged dimer, produced in Chinese hamster ovary (CHO), glycoform alfa; human signal-regulatory protein alpha (SIRPα, tyrosine-protein phosphatase non-receptor type substrate 1, inhibitory receptor SHPS-1), natural [L¹⁴>S, T²⁰>S, T²²>I, R²⁴>H, A²⁷>V, G⁴⁵>A, D⁶⁵>E, L⁶⁶>S, N⁷⁰>E, R⁷⁷>S, G⁷⁹>S, D¹⁰¹>del, V¹⁰²>T¹⁰¹]-variant, N-terminal (1-118)-fragment [binding domain for CD47 (inhibitor of phagocytosis by macrophages)], fused to a C-terminal Fc fragment of human immunoglobulin G4 (119-347), IGHG4*01; hinge 119-130 [S¹²⁸>P]-variant; CH2 131-240; CH3 241-345; CHS 346-347; dimer (126-126':129-129')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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