Манфидокимаб
ManfidokimabМНН
Prop. INN (наименование, предложенное ВОЗ)
CAS
2428381-56-8
Химическое название
immunoglobulin G4-kappa, anti-[Homo sapiens IL4R (interleukin 4 receptor, IL4RA, IL-4RA, CD124)], humanized monoclonal antibody;
gamma4 heavy chain humanized (1-443) [VH (Homo sapiens IGHV1-2*02 (81.6%) -(IGHD) -IGHJ4*01 (92.3%) L123>S (111), CDR-IMGT [8.8.9] (26-33.51-58.97-105)) (1-116)-Homo sapiens IGHG4*01, G4v5 h P10 (CH1 (117-214), hinge 1-12 S10>P (224) (215-226), CH2 (227-336), CH3 (337-441), CHS (442-443)) (117-443)], (130-214')-disulfide with kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-39*01 (83.2%) -IGKJ4*01 (81.8%) K123>N (103), V124>L (104), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (222-222'':225-225'')- bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa
gamma4 heavy chain humanized (1-443) [VH (Homo sapiens IGHV1-2*02 (81.6%) -(IGHD) -IGHJ4*01 (92.3%) L123>S (111), CDR-IMGT [8.8.9] (26-33.51-58.97-105)) (1-116)-Homo sapiens IGHG4*01, G4v5 h P10 (CH1 (117-214), hinge 1-12 S10>P (224) (215-226), CH2 (227-336), CH3 (337-441), CHS (442-443)) (117-443)], (130-214')-disulfide with kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-39*01 (83.2%) -IGKJ4*01 (81.8%) K123>N (103), V124>L (104), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (222-222'':225-225'')- bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa
Структура
Иностранные названия
- Manfidokimabum (латинское)
- Manfidokimab (английское)
- Manfidokimab (немецкое)
- Manfidokimab (французское)
- Manfidokimab (испанское)
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