Гресонитамаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2413817-97-5

immunoglobulin scFv-scFv-scFc, anti-[Homo sapiens CLDN18 (SFTPJ, surfactant associated protein J) isoform 2, extracellular domain 1 (EC1)] and anti-[Homo sapiens CD3E (CD3e, CD3 epsilon)], single chain monoclonal antibody, bispecific;
IG single chain scFv-scFv-scFc, anti-CLDN18 and anti-CD3E (1-990) [scFv-VH-V-KAPPA anti-CLDN18 (1-248) [VH (Homo sapiens IGHV1-2*02 (98.0%) -(IGHD) -IGHJ6*01 (100%), CDR-IMGT [8.8.18] (25-33.51-58.97-114)) (1-125) -15-mer tris(tetraglycyl-seryl) linker (126-140) -V-KAPPA (Homo sapiens IGKV1-12*01 (94.7%) -IGKJ5*01 (91.7%) Q120>C (240), CDR-IMGT [6.3.9] (167-172.190-192.229-237)) (141-248)] -5-mer tetraglycyl-seryl linker (249-253) -[scFv-VH-V-LAMBDA anti-CD3E (254-502) [VH Musmus/Homsap (Mus musculus IGHV10-1*02 (91.9%) -(IGHD) -IGHJ3*01 (86.7%)/Homo sapiens IGHV3-73*01 (87.0%) -(IGHD) -IGHJ5*01 (100%), CDR-IMGT [8.10.16] (279-286.304-313.352-367)) (254-378) -15-mer tris(tetraglycyl-seryl) linker (379-393) -V-LAMBDA (Homo sapiens IGLV7-43*01 (85.1%) -IGLJ3*02 (100%), CDR-IMGT [9.3.9] (419-427.445-447.484-492)) (394-502)] -4-mer tetraglycyl linker (503-506) -[scFc (h-CH2-CH3)-(h-CH2-CH3) (507-990) [Homo sapiens IGHG1*03 h-CH2-CH3, nG1m1, G1v30 CH2 N84.4>G (hinge 6-15 (507-516), CH2 R83>C (578), N84.4>G (583), V85>C (588) (517-626), CH3 E12 (642), M14 (644) (627-731), CHS (732-733)) (507-733)] -30-mer hexakis(tetraglycyl-seryl) linker (734-763) -[Homo sapiens IGHG1*03 h-CH2-CH3, nG1m1, G1v30 CH2 N84.4>G (hinge 6-15 (764-773), CH2 R83>C (835), N84.4>G (840), V85>C (845) (774-883), CH3 E12 (899), M14 (901) (884-988), CHS (989-990)) (764-990)]], produced in Chinese hamster ovary (CHO) cells, non-glycosylated

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