Этакафусп альфа

Prop. INN (наименование, предложенное ВОЗ)

2852680-28-3

humanized immunoglobulin G1-kappa anti-(human CD8) fused at the C-terminus of one heavy chain, via peptide linker ⁴⁴⁹SGGGGSGGGGSGGGGS⁴⁶⁴, to a variant of human interleukin-2, glycoform alfa;
gamma 1 heavy chain (1-448) [VH (Homo sapiens IGHV1-69*01 - (IGHD) -IGHJ4*01, CDR-Kabat [5.17.10] (31-35.50-66.99-108)) (1- 119) -Homo sapiens IGHG1*03v (CH1 (120-217), hinge (218-232), CH2 L²³⁶>A, L²³⁷>A, G²³⁹>A (233-342), CH3 S³⁵⁶>C, T³⁶⁸>S, L³⁷⁰>A, Y⁴⁰⁹>V (343-447), CHS K449>del (448)) (120-448)] fused via a peptide linker ^449SGGGGSGGGGSGGGGS⁴⁶⁴ to human interleukin-2 (IL-2, T-cell grow factor (TCGF) fragment 21-153, [H³⁶>E⁴⁸⁰, R⁵⁸>E⁵⁰², F⁶²>A⁵⁰⁶, C¹⁴⁵>A⁵⁸⁹]-variant (465-597 in the current sequence), (222-214')-disulfide with kappa light chain (1'-214') [V-KAPPA (Homo sapiens IGKV1-39*01 -IGKJ4*01, CDR-Kabat [11.7.9] (24'-34'.50'-56'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (108'-214')]; (228-228'':231-231'':356-351'')-trisdisulfide with gamma 1 heavy chain (1''-449'') [VH (Homo sapiens IGHV1-69*01 -(IGHD) - IGHJ4*01, CDR-Kabat [5.17.10] (31''-35''.50''-66''.99''-108'')) (1''- 119'') -Homo sapiens IGHG1*03v (CH1 (120''-217''), hinge (218''- 232''), CH2 L²³⁶''>A, L²³⁷''>A, G²³⁹''>A (233''-342''), CH3 Y351''>C, T³⁶⁸''>W (343''-447''), CHS (448''-449'')) (120''-449'')], (222''-214''')- disulfide with kappa light chain (1'''-214''') [V-KAPPA (Homo sapiens IGKV1-39*01 -IGKJ4*01, CDR-Kabat [11.7.9] (24'''-34'''.50'''- 56'''.89'''-97''')) (1'''-107''') -Homo sapiens IGKC*01 (108'''-214''')]; produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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