Эмилтатуг ледадотин

Prop. INN (наименование, предложенное ВОЗ)

2855974-40-0

immunoglobulin G1-kappa, anti-[Homo sapiens VTCN1(V-set domain containing T cell activation inhibitor 1, B7 family member H4, B7H4, B7-H4)], Homo sapiens monoclonal antibody; conjugated at glycosylated asparaginyl residues to a derivative of auristatin, with a ratio of 1 to 6, via a cleavable linker;
H-gamma1 heavy chain Homo sapiens (1-445) [VH (Homo sapiens IGHV3-53*01 (91.8%) -(IGHD) -IGHJ6*01 (93.8%), CDR-IMGT [8.7.10] (26-33.51-57.96-105)) (1-116) -Homo sapiens IGHG1*01 (100%), G1m17,1 CH1 K120, CH3 D12, L14 (CH1 K120 (213) (117-214), hinge 1-15 (215-229), CH2 (230-339), CH3 D12 (355), L14 (357) (340-444), CHS K2>del (445)) (117-445)], (219-216')-disulfide with L-kappa light chain Homo sapiens (1'-216') [V-KAPPA (Homo sapiens IGKV3-20*01 (100%) -IGKJ2*01 (100%), CDR-IMGT [7.3.10] (27'-33'.51'-53'.90'-99')) (1'-109') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (155'), V101 (193') (110'-216')]; dimer (225-225'':228-228'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-DG44, glycoform alfa; substituted at the side chain nitrogen atom of l-asparaginyl residues 296 and 296'' with a radical group consisting of 2-acetamido-[(5aRS,6SR,6aSR)-6-[(45S)-22,22-bis[(28S)-28-[(9S,14S)-9-carboxy-19-{[N,N-dimethyl-l-valyl-l-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(2R,3R)-3-methoxy-2-methyl-3-[(2S)-pyrrolidin-2-yl]propanoyl-l-phenylalanyl]amino}-14-methyl-3,7,12,15-tetraoxo-2,16-dioxa-4,8,13-triazanonadecan-1-yl]-27,30,33,36,39,42,46-heptaoxo-2,5,8,11,14,17,20,23,49-nonaoxa-26,29,32,35,38,41,45-heptaazapentacontan-50-yl]-45-[(9S,14S)-9-carboxy-19-{[N,N-dimethyl-l-valyl-l-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(2R,3R)-3-methoxy-2-methyl-3-[(2S)-pyrrolidin-2-yl]propanoyl-l-phenylalanyl]amino}-14-methyl-3,7,12,15-tetraoxo-2,16-dioxa-4,8,13-triazanonadecan-1-yl]-3,14,17,20,27,31,34,37,40,43,46-undecaoxo-2,7,10,24,50,53,56,59,62,65,68,71-dodecaoxa-4,13,18,21,28,32,35,38,41,45,47-undecaazadoheptacontan-1-yl]-1,4,5,5a,6,6a,7,8-octahydrocyclopropa[5,6]cycloocta[1,2-d][1,2,3]triazol-1-yl]-2,6-dideoxy-b-d-galactopyranosyl-(1®4)-2-acetamido-2-deoxy-6-O-(H or 6-deoxy-a-l-galactopyranosyl)-b-d-glucopyranosyl (ledadotin)

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